MANUEL SARMIENTO SOTO

Categoría
Profesor Titular de Universidad

Contacto

Correo electrónico
Área
Bioquímica y Biología Molecular

Investigación

Grupo de investigación

MECANISMOS DE MUERTE CELULAR EN ENFERMEDADES NEURODEGENERATIVAS (NEURODEGENERACIÓN)

Proyectos y contratos de investigación

ESTUDIO DE LA POSIBLE INFLUENCIA DE LOS PROCESOS INFLAMATORIOS PERIFÉRICOS SOBRE LA DEGENERACIÓN DEL SISTEMA DOPAMINÉRGICO NEGRO- ESTRIATAL (SAF2008-04366 - Investigador/a)
Ayuda a la Consolidación del Grupo de Investigación BIO-158 (2009/BIO-158 - Investigador/a)
Incentivo al Grupo de Investigación BIO-158 (2010/BIO-158 - Investigador/a)
Estudio ESTUDIO DE LOS CAMBIOS QUE EXPERIMENTAN CON EL ENVEJECIMIENTO LAS RUTAS QUE PROMUEVEN LA SUPERVIVENCIA CELULAR Y LA INFLAMACION CEREBRAL: MODU (P09-CTS-5244; 2010 - Investigador/a)

Capítulos en Libros

Sarmiento-Soto, Manuel:
Mouse Models of Brain Metastasis for Unravelling Tumour Progression. Pág. 231-244. Springer Nature. Springer Nature. 2016.

Participación en congresos

Sarmiento-Soto, Manuel:
Endothelial activation in brain metastasis . LIVERPOOL, GRAN BRETAÑA. 2011

Asistencia a congresos

Martinez-De Pablos, Rocio;Economopoulus, Vasiliki ;Herrera-Carmona, Antonio Jose;R.-sibson, Nicola;Machado-De La Quintana, Alberto;Venero-Recio, Jose Luis;Espinosa-Oliva, Ana Maria;Boza-serrano, Antonio ;Sarmiento-Soto, Manuel;Ruiz-Laza, Rocío;Santiago-Pavon, Martiniano;Oliva-Martín, María José;Roca-ceballos, María Angustias;Serres, Sebastian:
Ulcerative colitis induces the activation of microglia in the ventral mesencephalon along with dopaminergic neuronal death. . Poster en Congreso. XIII European Meeting on Glial Cells in Health and Disease. EDIMBURGO. REINO UNIDO. 2017
Espinosa-Oliva, Ana Maria;Martinez-De Pablos, Rocio;Delgado-Cortes, Maria Jose;Sarmiento-Soto, Manuel;Argúelles-Castilla, Sandro;Herrera-Carmona, Antonio Jose;Mauriño-Campanario, Raquel María;Fernandez-Villaran, Ruth;Venero-Recio, Jose Luis;Machado-De La Quintana, Alberto:
Chronic stress and sodium azide: a lethal combination for the mouse hippocampus. . Poster en Congreso. 16 National Congress of the Spanish Society of Neuroscience. Granada. 2015
Oliva-Martín, María José;Boza-serrano, Antonio;Espinosa-Oliva, Ana Maria;Martinez-De Pablos, Rocio;Sarmiento-Soto, Manuel;Santiago-Pavon, Martiniano;Herrera-Carmona, Antonio Jose;Venero-Recio, Jose Luis:
Ulcerative colitis as a potential risk factor for Parkinson's disease. Poster en Congreso. 9th FENS Forum. Milán. 2014
Espinosa-Oliva, Ana Maria;Martinez-De Pablos, Rocio;Sarmiento-Soto, Manuel;Fernandez-Villaran, Ruth;Herrera-Carmona, Antonio Jose;Cano-Garcia, Josefina;Machado-De La Quintana, Alberto:
Implication of dopamine in the recruitment of immune cells. . Comunicación en congreso. XV Congreso De La Sociedad Española De Neurociencia (SENC) (2013) Oviedo. Oviedo. 2013
Espinosa-Oliva, Ana Maria;Santiago-Pavon, Martiniano;Venero-Recio, Jose Luis;Herrera-Carmona, Antonio Jose;Cano-Garcia, Josefina;Machado-De La Quintana, Alberto;Hernandez-Romero, Maria Del Carmen;Delgado-Cortes, Maria Jose;Sarmiento-Soto, Manuel;Martínez-de Pablos, Rocío;Arguelles, Sandro;Bández, Manuel J;Fernández-villarán, Ruth;Mauriño-Campanario, Raquel María:
PERIPHERAL INFLAMMATION INCREASES THE DELETERIOUS EFFECT OF CNS INFLAMMATION ON THE NIGROSTRIATAL DOPAMINERGIC SYSTEM. Poster en Congreso. 8TH FENS FORUM OF NEUROSCIENCE. . 2012
Sarmiento-Soto, Manuel:
Interaction endothelium-cancer cell: Inevitable step towards brain metastases.. Poster en Congreso. keystone Symposia. DUBLIN - IRLANDA. 2012
Sarmiento-Soto, Manuel;Espinosa-Oliva, Ana Maria;Machado-De La Quintana, Alberto;Delgado-Cortes, Maria Jose;Argúelles-Castilla, Sandro;Martinez-De Pablos, Rocio;Fernandez-Villaran, Ruth;Van-Rooijen,N.;Venero-Recio, Jose Luis;Herrera-Carmona, Antonio Jose;Cano-Garcia, Josefina:
PERIPHERAL INFLAMMATION ENHANCES LIPOPOLYSACCHARIDE-INDUCED DAMAGE TO THE NIGROSTRIATAL DOPAMINERGIC SYSTEM: POSSIBLE IMPLICAION IN PARKINSON'S DISEAS. Poster en Congreso. 7 TH FENS FORUM OF EUROPEAN NEUROSCIENCE (7) (7.2010.AMSTERDAM). AMSTERDAM. 2010
Pasaro-Dionisio, M. Rosario;Ribas-Salgueiro, Juan Luis;Rodriguez Matarredona, Esperanza;Sarmiento-Soto, Manuel;Ribas-Serna, Juan:
RESPIRATORY RESPONSE TO SYSTEMIC INHIBITION OF THE NA+/H+ EXCHANGER TYPE 3 IN INTACT RATS. Comunicación en congreso. MEETING OF THE IINTERNATIONAL SOCIETY FOR ARTERIAL CHEMORECEPTION (17) (17.2008.VALLADOLID). VALLADOLID. 2008
Sarmiento-Soto, Manuel;Ribas-Salgueiro, Juan Luis;Ribas-Serna, Juan;Rodriguez Matarredona, Esperanza;Pasaro-Dionisio, M. Rosario:
¿SELECTIVE INHIBITION OF NA+/H+ TYPE 3 EXCHANGER ACTIVATES BRAINSTEM REGIONS INVOLVED IN CENTRAL CHEMORECEPTION AND HYDROELECTROLYTIC CONTROL¿.. Comunicación en congreso. 17TH INTERNATIONAL SYMPOSIUM ON THE AUTONOMIC NERVOUS SYSTEM (17) (17.2006.PUERTO RICO). PUERTO RICO. 2006

Artículos publicados

Folgado-dorado, Carlos;Sarmiento-Soto, Manuel;Carracena-de La Corte, Julia;Aguilera, Jose Raúl;Santana, Rafabel;Rivera Ramos, Alberto;Carbonero-Aguilar, Maria Del Pilar;Talaverón-Aguilocho, Rocío;Bautista-Palomas, Juan Dionisio:
Isolation and Purification of Fungal ß-Glucan as an Immunotherapy Strategy for Glioblastoma. Journal of Visualized Experiments. 2023. Vol: e64924. Pág. 1-17. 10.3791/64924.
Sarmiento-Soto, Manuel:
The Role of the Immune Response in Brain Metastasis. Frontiers in Oncology. 2022.
Sarmiento-Soto, Manuel:
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration. Cell Death & Disease. 2022.
Hajji-, Nabil;Mateos-Cordero, Santiago;Shah, Khalid;Bomalaski, John;Anichini, Giulio;Tzakos, Andreas G;Crook, Timothy;O¿neill, Kevin;Scheck, Adrienne C;Venero-Recio, Jose Luis;Syed, Nelofer;García-revilla, Juan;Sarmiento-Soto, Manuel;Perryman, Richard;Symington, Jake;Quarles, Chad C;Healey, Deborah R;Guo, Yijie;Orta-Vázquez, Manuel Luis:
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors. Journal of Clinical Investigation. 2022. Vol: 132. https://www.jci.org/articles/view/142137.
Sarmiento-Soto, Manuel:
STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction. Cancer Research. 2021.
Sarmiento-Soto, Manuel:
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis mode. Journal of Cerebral Blood Flow and Metabolism. 2021.
Sarmiento-Soto, Manuel:
VCAM-1 targeted alpha-particle therapy for early brain metastases. Neuro-Oncology. 2020.
Sarmiento-Soto, Manuel:
Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy. Molecular Cancer Therapeutics. 2019.
García-revilla, Juan;Santiago-Pavon, Martiniano;Rodriguez-Gómez, Jose Antonio;Sarmiento-Soto, Manuel;Martinez-De Pablos, Rocio;Venero-Recio, Jose Luis;Alonso, Isabel Maria;Burguillos-García, Miguel Angel;Herrera-Carmona, Antonio Jose;Ruiz-Laza, Rocío;Espinosa-Oliva, Ana Maria;Cruz, Luis;García-domínguez, Irene;Roca, Mª Angustias:
Reformulating pro-oxidant microglia in neurodegeneration. Journal of Clinical Medicine. 2019. Vol: 8. Núm: 10. 10.1016/j.celrep.2019.09.013.
Sarmiento-Soto, Manuel:
Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases. Theranostics. 2018.
Sarmiento-Soto, Manuel:
The Multifarious Role of Microglia in Brain Metastasis. Frontiers In Cellular Neuroscience. 2018. 10.3389/fncel.2018.00414.
Sarmiento-Soto, Manuel:
VCAM-1 targeted magnetic resonance imaging enables detection of brain micrometastases from different primary tumours. Clinical Cancer Research. 2018. 10.1158/1078-0432.CCR-18-1889.
Sarmiento-Soto, Manuel:
Optimization of molecularly targeted MRI in brain: empirical comparison of sequences and particles. International Journal of Nanomedicine. 2018. 10.2147/IJN.S158071.
Sarmiento-Soto, Manuel:
Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI. Nature Communications. 2017.
Sarmiento-Soto, Manuel:
Anti-inflammatory Microglia/Macrophages As a Potential Therapeutic Target in Brain Metastasis. Frontiers in Oncology. 2017.
Sarmiento-Soto, Manuel:
Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth. Oncotarget. 2016.
Delgado-Cortes, Maria Jose;Martinez-De Pablos, Rocio;Espinosa-Oliva, Ana Maria;Sarmiento-Soto, Manuel;Argúelles-Castilla, Sandro;Herrera-Carmona, Antonio Jose;Mauriño-Campanario, Raquel María;Fernandez-Villaran, Ruth;Venero-Recio, Jose Luis;Machado-De La Quintana, Alberto:
Synergistic deleterious effect of chronic stress and sodium azide in the mouse hippocampus.. Chemical Research in Toxicology. 2015. Vol: 28. Núm: 4. Pág. 651-661. 10.1021/tx5004408.
Sarmiento-Soto, Manuel:
Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion. Current Biology. 2015.
Martinez-De Pablos, Rocio;Herrera-Carmona, Antonio Jose;Espinosa-Oliva, Ana Maria;Sarmiento-Soto, Manuel;Muñoz-Pinto, Mario Faustino;Machado-De La Quintana, Alberto;Venero-Recio, Jose Luis:
Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation. Journal of Neuroinflammation. 2014. Vol: 11. Núm: 1. Pág. 34-44. 10.1186/1742-2094-11-34.
Machado-De La Quintana, Alberto;Delgado-Cortes, Maria Jose;Argúelles-Castilla, Sandro;Cano-Garcia, Josefina;Herrera-Carmona, Antonio Jose;Martinez-De Pablos, Rocio;Espinosa-Oliva, Ana Maria;Sarmiento-Soto, Manuel;Ayala-Gomez, Antonio;Venero-Recio, Jose Luis;Santiago-Pavon, Martiniano;Fernandez-Villaran, Ruth:
Chronic stress as a risk factor for Alzheimer's disease. Reviews in the Neurosciences. 2014. Vol: 25. Núm: 6. Pág. 785-804. 10.1515/revneuro-2014-0035.
Martinez-De Pablos, Rocio;Sarmiento-Soto, Manuel;Espinosa-Oliva, Ana Maria:
Creating a rat model of chronic variate stress. Bio-Protocol. 2014. Vol: 4. Núm: 23. Pág. 1-7. 10.21769/BioProtoc.1315 .
Sarmiento-Soto, Manuel:
Functional role of endothelial adhesion molecules in the early stages of brain metastasis. Neuro-Oncology. 2014.
Martinez-De Pablos, Rocio;Espinosa-Oliva, Ana Maria;Sarmiento-Soto, Manuel;Venero-Recio, Jose Luis:
Stress and inflammation: a detrimental combination in the development of neurodegenerative disease. Inflammation and Cell Signaling. 2014. Vol: 1.
Sarmiento-Soto, Manuel:
Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker. The Journal of Nuclear Medicine. 2014.
Sarmiento-Soto, Manuel:
Structural and functional effects of metastases in rat brain determined by multimodal MRI. International Journal of Cancer. 2014.
Espinosa-Oliva, Ana Maria;Martinez-De Pablos, Rocio;Sarmiento-Soto, Manuel;Fernandez-Villaran, Ruth;Carrillo-Jimenez, Alejandro;Santiago-Pavon, Martiniano;Venero-Recio, Jose Luis;Herrera-Carmona, Antonio Jose;Machado-De La Quintana, Alberto:
Role of dopamine in the recruitment of inmune cells to the nigrostriatal dopaminergic structures. Neurotoxicology. 2014. Vol: 41. Núm: C. Pág. 89-101. 10.1016/j.neuro.2014.01.006.
Sarmiento-Soto, Manuel:
ASPP2 controls epithelial plasticity and inhibits metastasis through ß-catenin-dependent regulation of ZEB1. Nature Cell Biology. 2014.
Martinez-De Pablos, Rocio;Sarmiento-Soto, Manuel:
Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis.. Journal of Cerebral Blood Flow and Metabolism. 2013. Vol: 33. Núm: 5. Pág. 744-753. 10.1038/jcbfm.2013.12..
Sarmiento-Soto, Manuel:
Molecular MRI enables early and sensitive detection of brain metastases. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2012.
Machado-De La Quintana, Alberto;Delgado-Cortes, Maria Jose;Mauriño-Campanario, Raquel María;Cano-Garcia, Josefina;Herrera-Carmona, Antonio Jose;Venero-Recio, Jose Luis;Santiago-Pavon, Martiniano;Martinez-De Pablos, Rocio;Fernandez-Villaran, Ruth;Espinosa-Oliva, Ana Maria;Argúelles-Castilla, Sandro;Sarmiento-Soto, Manuel:
Inflammatory animal models for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degener. ISRN Neurology. 2011. Vol: 2011. Pág. 1-16. 10.5402/2011/476158.
Machado-De La Quintana, Alberto;Delgado-Cortes, Maria Jose;Mauriño-Campanario, Raquel María;Cano-Garcia, Josefina;Herrera-Carmona, Antonio Jose;Venero-Recio, Jose Luis;Santiago-Pavon, Martiniano;Martinez-De Pablos, Rocio;Fernandez-Villaran, Ruth;Espinosa-Oliva, Ana Maria;Argúelles-Castilla, Sandro;Sarmiento-Soto, Manuel:
Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in Prkinson's dise. Parkinson's Disease. 2011. Vol: 2011. Pág. 1-9. 10.4061/2011/393769.
Espinosa-Oliva, Ana Maria;Martinez-De Pablos, Rocio;Fernandez-Villaran, Ruth;Sarmiento-Soto, Manuel;Herrera-Carmona, Antonio Jose;Machado-De La Quintana, Alberto:
PROAGING EFFECTS OF STRESS: A REVIEW. Medicina Antienvejecimiento. 2010. Vol: 14. Pág. 33-54.
Martinez-De Pablos, Rocio;Villaran-Fernandez,Ruth;Espinosa-Oliva, Ana Maria;Cano-,Josefina;Machado-De La Quintana, Alberto;Sarmiento-Soto, Manuel;De Pablos-,Rocio;Argüelles-,Sandro;Delgado-Cortes, Maria Jose;Sobrino-Cabello, Verónica;Van Rooijen-,Nico;Venero-Recio, Jose Luis;Herrera-,A.J.:
ULCERATIVE COLITIS EXACERBATES LIPOPOLYSACCHARIDE-INDUCED DAMAGE TO THE NIGRAL DOPAMINERGIC SYSTEM: POTENTIAL RISK FACTOR IN PARKINSON`S DISEASE. Journal of Neurochemistry. 2010. Vol: 114. Núm: 6. Pág. 1687-1700.
Pasaro-Dionisio, M. Rosario;Ribas-Salgueiro, Juan Luis;Rodriguez-Matarredona, Esperanza;Sarmiento-Soto, Manuel;Ribas-Serna, Juan:
SYSTEMIC INHIBITION OF THE NA(+)/H (+) EXCHANGER TYPE 3 IN INTACT RATS ACTIVATES BRAINSTEM RESPIRATORY REGIONS.. Advances in Experimental Medicine and Biology. 2009. Vol: 648. Pág. 395-401.
Ribas-Salgueiro, Juan Luis;Rodriguez Matarredona, Esperanza;Sarmiento-Soto, Manuel;Ribas-Serna, Juan;Pasaro-Dionisio, M. Rosario:
RESPIRATORY RESPONSE TO SYSTEMIC INHIBITION OF THE NA+/H+ EXCHANGER TYPE 3 IN INTACT RATS. Respiratory Physiology & Neurobiology. 2009. Vol: 165. Pág. 254-260. 10.1016/j.resp.2008.12.011.
Ribas-Serna, Juan;Sarmiento-Soto, Manuel;Rodriguez Matarredona, Esperanza;Ribas-Salgueiro, Juan Luis;Pasaro-Dionisio, M. Rosario:
INHIBITION OF NA+/H+ EXCHANGER TYPE 3 INCREASES BREATHING FREQUENCY AND ACTIVATES CENTRAL CARDIORESPIRATORY NEURONS IN RATS. Acta Physiologica. 2007. Vol: 190. Núm: SUPP 655. Pág. 54-55.
Sarmiento-Soto, Manuel;Rodriguez-Matarredona, Esperanza;Ribas-Salgueiro, Juan Luis;Ribas-Serna, Juan;Pasaro-Dionisio, M. Rosario:
SELECTIVE INHIBITION OF NA+/H+ EXCHANGER TYPE 3 ACTIVATES BRAINSTEM REGIONS INVOLVED IN CENTRAL CHEMORECEPTION AND HYDROELECTROLYTIC CONTROL. Clinical Autonomic Research. 2006. Vol: 16. Núm: 5. Pág. 326-326.
Sarmiento-Soto, Manuel:
CHRONIC STRESS SHOULD BE CONSIDERED A RISK FACTOR FOR ALZHEIMER¿S DISEASE. Journal of Neurochemistry.