Directorio
ELENA GAVILAN DORRONZORO
Categoría
María Zambrano(Investigador Distinguido)
Contacto
Correo electrónico
Departamento
Área
Bioquímica y Biología Molecular
Docencia
Asignaturas que imparte
Investigación
Proyectos y contratos de investigación
SEÑALIZACIÓN ASOCIADA A MEMBRANAS INTRACELULARES EN CONDICIONES NORMALES Y PATOLÓGICAS: IMPLICACIONES EN ENFERMEDADES NEURODEGENERATIVAS. (P07-CVI-03199 - Investigador/a)
PAPEL DE LA AUTOFAGIA EN PROCESOS NEURODEGENERATIVOS INDUCIDOS POR DISFUNCIÓN DEL PROTEASOMA O DAÑO ISQUÉMICO: IMPLICACIÓN DEL ENVEJECIMIENTO Y LA INF (PS09/00848 - Investigador/a)
Investigador Postdoctoral (Investigador/a)
Investigador Postdoctoral (Investigador/a)
Identificación de mecanismos de resistencia a nuevos anticuerpos anti-HER en cáncer de mama (PI12/00680 - Investigador/a)
Papel de proteínas del área centrosoma/aparato de Golgi en la formación del cilio primario: análisis en células crecidas en micro-moldes y en el desar (CTS 2071 - Investigador/a)
Disección de la contribución del centrosoma y el aparato de golgi a la arquitectura y polaridad celulares (BFU2015-65747-P - Investigador/a)
Efecto de la neuroinflamacion sobre la activación de las vías UPR, ERAD Y Akt/GSK3/b-catenina en respuesta al bloqueo del proteosoma. Relación con la (PI12/00445 - Investigador/a)
Asistencia a congresos
Gavilán-Dorronzoro, Elena;Roca, Jesús;Rios-Sanchez, Rosa Maria:
CONTRIBUTION OF CENTROSOME- AND GOLGI APPARATUS-MICROTUBULE NUCLEATION TO EPITHELIAL POLARIZATION. Poster en Congreso. 1st Joint Congress of the Spanish Societies for Cell Biology, genetics and Developmental Biology. ASTURIAS (GIJÓN). 2017
CONTRIBUTION OF CENTROSOME- AND GOLGI APPARATUS-MICROTUBULE NUCLEATION TO EPITHELIAL POLARIZATION. Poster en Congreso. 1st Joint Congress of the Spanish Societies for Cell Biology, genetics and Developmental Biology. ASTURIAS (GIJÓN). 2017
Ruano, Diego;Gavilán-Dorronzoro, María De La Paz;Pintado-Losa, Cristina;Gavilán-Dorronzoro, Elena;Castaño-Navarro, Angelica:
Neuroinflammation, autophagy and proteasome. Sesión plenaria en Congreso. 6th Conference of the Mediterranean Neuroscience Society. La Valetta (Malta). 2017
Neuroinflammation, autophagy and proteasome. Sesión plenaria en Congreso. 6th Conference of the Mediterranean Neuroscience Society. La Valetta (Malta). 2017
Gavilán-Dorronzoro, Elena;Pintado-Losa, Cristina;Gavilán-Dorronzoro, María De La Paz;Daza-Navarro, Paula;Sanchez-Aguayo, Inmaculada;Castaño-Navarro, Angelica;Ruano, Diego:
Defective cross-talk between the ubiquitin proteasome system and the autophagy lysosomal pathway under proteasome stress in aged rat hippocampus. Poster en Congreso. 40th FEBS Congress. The Biochemical Basis of Life. . Berlin, Alemania. 2015
Defective cross-talk between the ubiquitin proteasome system and the autophagy lysosomal pathway under proteasome stress in aged rat hippocampus. Poster en Congreso. 40th FEBS Congress. The Biochemical Basis of Life. . Berlin, Alemania. 2015
Daza-Navarro, Paula;Gavilán-Dorronzoro, Elena;Giraldez-Macias, Servando;Sanchez-Aguayo, Inmaculada;Romero-Portillo, Francisco;Ruano, Diego:
Breast cancer cell line MCF7 escapes from G1/ S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. Poster en Congreso. 40th FEBS Congress. Berlin, GERMANY. 2015
Breast cancer cell line MCF7 escapes from G1/ S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. Poster en Congreso. 40th FEBS Congress. Berlin, GERMANY. 2015
Gavilán-Dorronzoro, Elena;Pintado-Losa, Cristina;Gavilán-Dorronzoro, María De La Paz;Daza-Navarro, Paula;Sanchez-Aguayo, Inmaculada;Castaño-Navarro, Angelica;Ruano, Diego:
Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress. Role of GSK-3¿ as master regulat. Comunicación en congreso. XVI Congress SEBC. . 2015
Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress. Role of GSK-3¿ as master regulat. Comunicación en congreso. XVI Congress SEBC. . 2015
Gavilán-Dorronzoro, Elena;Giraldez-Macias, Servando;Sanchez-Aguayo, Inmaculada;Romero-Portillo, Francisco;Martín-Rubio, María Esther;Macías, Sandra ;Ruano, Diego;Daza-Navarro, Paula:
A GSK-3ß dependent mechanism is the responsible for the escape of the breast cancer cell line MCF7 from G1/S arrest induced by proteasome inhibition. Poster en Congreso. XVI congreso de la Sociedad Española de Biología Celular. Seville, Spain. 2015
A GSK-3ß dependent mechanism is the responsible for the escape of the breast cancer cell line MCF7 from G1/S arrest induced by proteasome inhibition. Poster en Congreso. XVI congreso de la Sociedad Española de Biología Celular. Seville, Spain. 2015
Gavilán-Dorronzoro, Elena:
Mejora terapéutica de la modulación autofágica en cáncer / Therapeutic advantage of autophagy modulation in cancer. Ponencia en Congreso. 11º Simposio Internacional de Oncología Traslacional. Casa de Convalescència ¿ Fundació UAB, Barcelona. 2015
Mejora terapéutica de la modulación autofágica en cáncer / Therapeutic advantage of autophagy modulation in cancer. Ponencia en Congreso. 11º Simposio Internacional de Oncología Traslacional. Casa de Convalescència ¿ Fundació UAB, Barcelona. 2015
Gavilán-Dorronzoro, Elena;Daza-Navarro, Paula;Sanchez-Aguayo, Inmaculada;Castaño-Navarro, Angelica;Ruano, Diego:
Defective cross-talk between the UPS and the ALP in aged rats subjected to proteasome stress: role of GSK-3beta as master regulator. . Comunicación en congreso. Joint Meeting of Nordic, Spanish and French Autophagy Networks . Toulouse, France. 2014
Defective cross-talk between the UPS and the ALP in aged rats subjected to proteasome stress: role of GSK-3beta as master regulator. . Comunicación en congreso. Joint Meeting of Nordic, Spanish and French Autophagy Networks . Toulouse, France. 2014
Gavilán-Dorronzoro, Elena;Daza-Navarro, Paula;Sanchez-Aguayo, Inmaculada;Ruano, Diego:
Phosphorylated GSK3 increases in tumoral MCF7 cells following proteasome inhibition; involvement in autophagy-mediated cell death. Poster en Congreso. XIV Congreso de la SEBC. . 2011
Phosphorylated GSK3 increases in tumoral MCF7 cells following proteasome inhibition; involvement in autophagy-mediated cell death. Poster en Congreso. XIV Congreso de la SEBC. . 2011
Pintado-Losa, Cristina;Gavilán-Dorronzoro, María De La Paz;Gavilán-Dorronzoro, Elena;Gutierrez-,Antonia;Vitorica-Ferrandez, Francisco Javier;Castaño-Navarro, Angelica;Rios-Sanchez, Rosa Maria;Ruano, Diego:
LA NEUROINFLAMACIÓN Y LA DISFUNCIÓN DEL PROTEOSOMA ACTÚAN COMO FACTORES SINÉRGICOS FAVORECIENDO LA AGREGACIÓN DE PROTEÍNAS EN EL HIPOCAMPO DE LA RATA . Poster en Congreso. XIV CONGRESO NACIONAL DE LA SOCIEDAD ESPAÑOLA DE NEUROCIENCIA () (.2011.SALAMANCA). SALAMANCA. 2011
LA NEUROINFLAMACIÓN Y LA DISFUNCIÓN DEL PROTEOSOMA ACTÚAN COMO FACTORES SINÉRGICOS FAVORECIENDO LA AGREGACIÓN DE PROTEÍNAS EN EL HIPOCAMPO DE LA RATA . Poster en Congreso. XIV CONGRESO NACIONAL DE LA SOCIEDAD ESPAÑOLA DE NEUROCIENCIA () (.2011.SALAMANCA). SALAMANCA. 2011
Ruano, Diego;Gavilán-Dorronzoro, María De La Paz;Pintado-Losa, Cristina;Gavilán-Dorronzoro, Elena;Vitorica-Ferrandez, Francisco Javier;Castaño-Navarro, Angelica:
QUALITATIVE AND QUANTITATIVE AGE-RELATED DIFFERENCES IN THE PROTEASOME BIOGENESIS INDUCED BY PROTEIN ACCUMULATION: ROLE OF NEUROINFLAMMATION. Poster en Congreso. 7TH FENS FORUM OF EUROPEAN NEUROSCIENCE () (.2010.AMSTERDAM). AMSTERDAM. 2010
QUALITATIVE AND QUANTITATIVE AGE-RELATED DIFFERENCES IN THE PROTEASOME BIOGENESIS INDUCED BY PROTEIN ACCUMULATION: ROLE OF NEUROINFLAMMATION. Poster en Congreso. 7TH FENS FORUM OF EUROPEAN NEUROSCIENCE () (.2010.AMSTERDAM). AMSTERDAM. 2010
Artículos publicados
Gabasa, Marta;Maqueda, Maria;Davalos, Albert;Gavilán-Dorronzoro, Elena;Perera, Alexandre;Ramírez, Josep;Gascón, Pere;Reguart, Noemí;Roz, Luca ;Radisky, Derek C;Alcaraz, Jordi;Radisky, Evette S;Ikemori, Rafael;Bertolini, Giulia;Arshakyan, Marselina;Hockla, Alexandra;Duch, Paula;Rondinone, Ornella;Llorente, Alejandro:
MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence.. Cancer Letters. 2021. Vol: 507. Núm: 1. Pág. 1-12. 10.1016/j.canlet.2021.01.028.
MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence.. Cancer Letters. 2021. Vol: 507. Núm: 1. Pág. 1-12. 10.1016/j.canlet.2021.01.028.
Chaalal, Makhlouf;Gavilán-Dorronzoro, Elena;Louaileche, Hayette ;Ruano, Diego;Parrado-Rubio, Juan;Castaño-Navarro, Angelica:
Anti-inflammatory activity of phenolic extracts from different parts of prickly pear on lipopolysaccharide-stimulated N13 microglial cells. International Journal of Phytomedicine. 2015. Vol: 7. Núm: 4. Pág. 411-419.
Anti-inflammatory activity of phenolic extracts from different parts of prickly pear on lipopolysaccharide-stimulated N13 microglial cells. International Journal of Phytomedicine. 2015. Vol: 7. Núm: 4. Pág. 411-419.
Daza-Navarro, Paula;Gavilán-Dorronzoro, Elena;Giraldez-Macias, Servando;Sanchez-Aguayo, Inmaculada;Romero-Portillo, Francisco;Ruano, Diego:
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. The FEBS Journal. 2015. Vol: 282. Núm: Supplement 1. Pág. 159-159.
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. The FEBS Journal. 2015. Vol: 282. Núm: Supplement 1. Pág. 159-159.
Lazzari, Luca ;González, Iria ;Iglesias, Mar ;Gavilán-Dorronzoro, Elena;Corti, Giorgio ;Hobor, Sebastijan ;Crisafulli, Giovanni ;Salido, Marta ;Sánchez, Juan ;Dalmases, Alba;Bellmunt, Joaquim ;Arena, Sabrina;De Fabritiis, Gianni ;Rovira, Ana ;Di Nicolantonio, Federica ;Albanell, Joan ;Bardelli, Alberto ;Montagut, Clara ;Bellosillo, Beatriz ;Siravegna, Giulia ;Martínez, Alejandro ;Cañadas, Israel;Ferruz, Noelia;Russo, Mariangela ;Misale, Sandra :
Proceedings: AACR 106th Annual Meeting 2015; Abstract 3588: Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorecta. Cancer Research. 2015. Vol: 75. Núm: 15. https://doi.org/10.1158/1538-7445.AM2015-3588.
Proceedings: AACR 106th Annual Meeting 2015; Abstract 3588: Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorecta. Cancer Research. 2015. Vol: 75. Núm: 15. https://doi.org/10.1158/1538-7445.AM2015-3588.
Gavilán-Dorronzoro, Elena;Pintado-Losa, Cristina;Gavilán-Dorronzoro, María De La Paz;Daza-Navarro, Paula;Sanchez-Aguayo, Inmaculada;Castaño-Navarro, Angelica;Ruano, Diego:
Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress.. Neurobiology of Aging. 2015. Vol: 36. Núm: 5. Pág. 1953-1963. 10.1016/j.neurobiolaging.2015.02.025.
Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress.. Neurobiology of Aging. 2015. Vol: 36. Núm: 5. Pág. 1953-1963. 10.1016/j.neurobiolaging.2015.02.025.
Montagut, Clara;Cañadas, Israel;Gavilán-Dorronzoro, Elena;Arpi, Oriol;Bellosillo, Beatriz ;Martinez, Alejandro ;Dalmases, Alba ;Rovira, Ana;Albanell, Joan:
Sym004 to circumvent resistance to cetuximab driven by emergence of EGFR extracellular mutations in colorectal cancer.. Journal of Clinical Oncology. 2015. Vol: 33. Núm: 15. http://ascopubs.org/doi/abs/10.1200/jco.2015.33.15_suppl.e13600.
Sym004 to circumvent resistance to cetuximab driven by emergence of EGFR extracellular mutations in colorectal cancer.. Journal of Clinical Oncology. 2015. Vol: 33. Núm: 15. http://ascopubs.org/doi/abs/10.1200/jco.2015.33.15_suppl.e13600.
Gavilán-Dorronzoro, Elena;Giraldez-Macias, Servando;Sanchez-Aguayo, Inmaculada;Romero-Portillo, Francisco;Ruano, Diego;Daza-Navarro, Paula:
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. Scientific Reports. 2015. Vol: 5. Núm: 10027. Pág. 1-13. doi: 10.1038/srep10027.
Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3ß dependent mechanism. Scientific Reports. 2015. Vol: 5. Núm: 10027. Pág. 1-13. doi: 10.1038/srep10027.
Martinez, Alejandro ;Mullane, Stephanie A. ;Choueiri, Toni K. ;Rovira, Ana ;Albanell, Joan ;Brake, Rachael ;Bellmunt, Joaquim ;Hernandez, Anna ;Arpi, Oriol ;Menendez, Silvia ;Iarchouk, Natalia ;Gavilán-Dorronzoro, Elena;Bellosillo, Beatriz ;Arumí, Montserrat ;Rojo, Federico :
Targeting the PI3K/AKT/mTOR pathway with MLN0128 (mTORC1/2 inh) and MLN1117 (PI3K alpha inh) in bladder cancer: Rational for its testing in clinical t. Journal of Clinical Oncology. 2015. Vol: 33. Núm: 7. https://doi.org/10.1200/jco.2015.33.7_suppl.369.
Targeting the PI3K/AKT/mTOR pathway with MLN0128 (mTORC1/2 inh) and MLN1117 (PI3K alpha inh) in bladder cancer: Rational for its testing in clinical t. Journal of Clinical Oncology. 2015. Vol: 33. Núm: 7. https://doi.org/10.1200/jco.2015.33.7_suppl.369.
Arena, Sabrina;González, Iria ;Iglesias, Mar;Gavilán-Dorronzoro, Elena;Corti, Giorgio ;Hobor, Sebastijan ;Crisafulli, Giovanni ;Salido, Marta;Sánchez, Juan;Dalmases, Alba;Bellmunt, Joaquim ;Bellosillo, Beatriz ;De Fabritiis, Gianni ;Rovira, Ana;Di Nicolantonio, Federica ;Albanell, Joan ;Bardelli, Alberto ;Montagut, Clara ;Siravegna, Giulia ;Martínez, Alejandro ;Cañadas, Israel ;Lazzari, Luca ;Ferruz, Noelia ;Russo, Mariangela ;Misale, Sandra :
Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer. Clinical Cancer Research. 2015. Vol: 21. Núm: 9. Pág. 2157-66. 10.1158/1078-0432.CCR-14-2821.
Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer. Clinical Cancer Research. 2015. Vol: 21. Núm: 9. Pág. 2157-66. 10.1158/1078-0432.CCR-14-2821.
Enriquez-barreto, Lilian;Morales, Migeul;Cuesto, German;Domínguez-iturza, Nuria;Gavilán-Dorronzoro, Elena;Ruano, Diego;Sandi, Carmen;Fernández-ruíz, Antonio;Martín-vázquez, Gonzalo;Herreras, Oscar:
Learning improvement after PI3K activation correlates with de novo formation of functional small spines. Frontiers in Molecular Neuroscience. 2014. Vol: 6. Núm: 54. Pág. 1-17. 10.3389/fnmol.2013.00054.
Learning improvement after PI3K activation correlates with de novo formation of functional small spines. Frontiers in Molecular Neuroscience. 2014. Vol: 6. Núm: 54. Pág. 1-17. 10.3389/fnmol.2013.00054.
Gavilán-Dorronzoro, Elena;Sanchez-Aguayo, Inmaculada;Daza-Navarro, Paula;Ruano, Diego:
GSK-3b signaling determines autophagy activation in the breast tumorcell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in respon. Cell Death & Disease. 2013. Vol: 4. Núm: e572. Pág. 1-11. 10.1038/cddis.2013.95.
GSK-3b signaling determines autophagy activation in the breast tumorcell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in respon. Cell Death & Disease. 2013. Vol: 4. Núm: e572. Pág. 1-11. 10.1038/cddis.2013.95.
Gavilán-Dorronzoro, María De La Paz;Pintado-Losa, Cristina;Gavilán-Dorronzoro, Elena;García-cuervo, María Luisa;Castaño-Navarro, Angelica;Rios-Sanchez, Rosa Maria;Ruano, Diego:
Age-related differences in the dynamics of hippocampal proteasome recovery. Journal of Neurochemistry. 2012. Vol: 123. Núm: 4. Pág. 635-644. 10.1111/j.1471-4159.2012.07932.x.
Age-related differences in the dynamics of hippocampal proteasome recovery. Journal of Neurochemistry. 2012. Vol: 123. Núm: 4. Pág. 635-644. 10.1111/j.1471-4159.2012.07932.x.
Gavilán-Dorronzoro, María De La Paz;Pintado-Losa, Cristina;Gavilán-Dorronzoro, Elena;García-cuervo, Luisa M.;Gutiérrez-Pérez, Antonia;Vitorica-Ferrandez, Francisco Javier;Castaño-Navarro, Angelica;Rios-Sanchez, Rosa Maria;Ruano, Diego:
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration ind. Journal of Neuroinflammation. 2012. Vol: 9. Núm: 1. Pág. 87-96. 10.1186/1742-2094-9-87.
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration ind. Journal of Neuroinflammation. 2012. Vol: 9. Núm: 1. Pág. 87-96. 10.1186/1742-2094-9-87.
Dasuri-,Kalavathi;Ebenezer-,Philip J.;Uranga-,Romina M.;Gavilán-Dorronzoro, Elena;Zhang-,Le;Fernandez-Kim-,Sun Ok;Bruce-Keller-,Annadora J.;Keller-,Jeffrey N.:
AMINO ACID ANALOG TOXICITY IN PRIMARY RAT NEURONAL AND ASTROCYTE CULTURES: IMPLICATIONS FOR PROTEIN MISFOLDING AND TDP-43 REGULATION.. Journal of Neuroscience Research. 2011. Vol: 89. Núm: 9. Pág. 1471-1477.
AMINO ACID ANALOG TOXICITY IN PRIMARY RAT NEURONAL AND ASTROCYTE CULTURES: IMPLICATIONS FOR PROTEIN MISFOLDING AND TDP-43 REGULATION.. Journal of Neuroscience Research. 2011. Vol: 89. Núm: 9. Pág. 1471-1477.
Ebenezer-,Philip J.;Weidner-,Adam M.;Keller-,Jeffrey N.;Levine-,Harry;Markesbery-,William R;Murphy-,M. Paul;Zhang-,Le;Dasuri-,Kalavathi;Fernandez-Kim-,Sun Ok;Bruce-Keller-,Annadora J.;Gavilán-Dorronzoro, Elena:
NEURON SPECIFIC TOXICITY OF OLIGOMERIC AMYLOID-ß: ROLE FOR JUN-KINASE AND OXIDATIVE STRESS.. Journal of Alzheimers Disease. 2010. Vol: 22. Núm: 3. Pág. 839-848.
NEURON SPECIFIC TOXICITY OF OLIGOMERIC AMYLOID-ß: ROLE FOR JUN-KINASE AND OXIDATIVE STRESS.. Journal of Alzheimers Disease. 2010. Vol: 22. Núm: 3. Pág. 839-848.
Dasuri-,Kalavathi;Ebenezer-,Philip J.;Zhang-,Le;Fernandez-Kim-,Sun Ok;Uranga-,Romina M.;Gavilán-Dorronzoro, Elena;Di Blasio-,Alessia;Keller-,Jeffrey N.:
SELECTIVE VULNERABILITY OF NEURONS TO ACUTE TOXICITY AFTER PROTEASOME INHIBITOR TREATMENT: IMPLICATIONS FOR OXIDATIVE STRESS AND INSOLUBILITY OF NEWLY. Free Radical Biology & Medicine. 2010. Vol: 49. Núm: 8. Pág. 1290-1297.
SELECTIVE VULNERABILITY OF NEURONS TO ACUTE TOXICITY AFTER PROTEASOME INHIBITOR TREATMENT: IMPLICATIONS FOR OXIDATIVE STRESS AND INSOLUBILITY OF NEWLY. Free Radical Biology & Medicine. 2010. Vol: 49. Núm: 8. Pág. 1290-1297.
Gavilán-Dorronzoro, María De La Paz;Pintado-Losa, Cristina;Gavilán-Dorronzoro, Elena;Jimenez-Muñoz, Sebastian;Rios-Sanchez, Rosa Maria;Vitorica-Ferrandez, Francisco Javier;Castaño-Navarro, Angelica;Ruano, Diego:
DYSFUNCTION OF THE UNFOLDED PROTEIN RESPONSE INCREASES NEURODEGENERATION IN AGED RAT HIPPOCAMPUS FOLLOWING PROTEASOME INHIBITION. Aging Cell. 2009. Vol: 8. Pág. 654-665.
DYSFUNCTION OF THE UNFOLDED PROTEIN RESPONSE INCREASES NEURODEGENERATION IN AGED RAT HIPPOCAMPUS FOLLOWING PROTEASOME INHIBITION. Aging Cell. 2009. Vol: 8. Pág. 654-665.
