CINTIA ROODVELDT

Categoría
Profesor Titular de Universidad

Contacto

Correo electrónico
Área
Bioquímica y Biología Molecular

Investigación

Grupo de investigación

TERAPIAS AVANZADAS EN INMUNOMODULACION Y NEUROPROTECCION (NIR Lab)

Proyectos y contratos de investigación

ARE THERE NATURAL AUTOEPITOPE-MIMICHING MELECULES WITH CYTOTOXIC ACTIVITY, CAPABLE OF PREVENTING AUTOIMMUNE DISEASE? A BASIC BIOLOGICAL QUESTION WITH (SAF2007-29418-E - Investigador/a)
ESTUDIO DE LA CAPACIDAD INMUNOREGULADORA DEL PÉPTIDO INTESTINAL VASOACTIVO (VIP) SOBRE CÉLULAS MADRE DERIVADAS DE TEJIDO ADIPOSO (CMDA) EN EL MODELO P (PS09/02252 - Investigador/a)
FINANCIACION DE LOS GRUPOS UNIVERSITARIOS DE INVESTIGACION Y DESARROLLO TECNOLOGICO DE LA COMUNIDAD AUNTONOMA ANDALUZA (HUM-321 - Investigador/a)
IMMUNOREGULATORY RESPONSE INDUCED BY IMMUNIZATION WITH CHAPERONE/ALPHA-SYNUCLEIN COMPLEXES AS A NOVEL APPROACH TO PARKINSON'S DISEASE THERAPY: BASIC O (CP10/00527 - Responsable)
IMMUNE REGULATION STUDIES BY ALPHA-SYNUCLEIN IN PARKINSON DISEASE. ROLE OF CO-CHAPERONES (FDF-2010-FEBS - Responsable)
NANOTECNOLOGÍA COMO PLATAFORMA DE DESARROLLO DE INMUNOTERAPIAS MEDIADAS POR NPS FUNCIONALIZADAS CON EL PEPTIDO INTESTINAL VASOACTIVO EN ENFERMEDADES I (CTS-6928 - Investigador/a)
DISEÑO E IMPLANTACIÓN DE PROGRAMAS Y PROYECTOS DE INNOVACIÓN E INVESTIGACIÓN BIOMÉDICA DEL SISTEMA SANITARIO PÚBLICO DE ANDALUCIA (0014/0013 - Investigador/a)
BIOMARCADORES. DESARROLLO Y APLICACIONES EN AGROALIMENTACIÓN Y SANIDAD (SI-015/07 - Investigador/a)
REALIZACIÓN DE PRUEBAS DE CONCEPTO PARA EL ESTUDIO DE LA ACTIVIDAD INMUNOMODULADORA DEL CONDROÍTIN SULFATO. (0541/0013 - Investigador/a)
PROGRAMAS DE I+D+I ESTRATÉGICOS EN TERAPIA GÉNICA, CELULAR Y NANOMEDICINA. DIRECCION AREA DESARROLLO DE LA PRODUCCIÓN CIENTÍFICA. FUNDACIÓN PÚBLICA AN (0013 - Investigador/a)
Signaling kinases and mechanisms of immunoregulation in amyotrophic lateral sclerosis (ALS) (PID2022-140838OB-I00 - Investigador Principal Consolidado)
Caracterización Funcional y de los Mecanismos de Acción mediados por la Kinasa de Señalización MOK en la Neuroinflamación asociada a la Esclerosis Lat (2019/FARECES/CROODVELT - Investigador Principal Consolidado)
Caracterización Funcional y de los Mecanismos de Acción mediados por MOK en la Neuroinflamación asociada a Proteinopatías Neurodegenerativas: Escleros (US-1265227 - Investigador Principal Consolidado)
Caracterización Funcional e Intervención de una Nueva Ruta de Señalización de la Neuroinflamación Mediada por Microglia en Esclerosis Lateral Amiotróf (RTI2018-098432-B-I00 - Investigador Principal Consolidado)
Mecanismos Moleculares de una Proteína de la Familia Bet en la Respuesta Neuroinflamatoria Asociada a Proteinopatías Neurodegenerativas (PY20_01097 - Investigador Principal Consolidado)
Programa 'Ramón y Cajal' 2017, Ministerio de Ciencia e Innovación de España (RYC-2017-23127 - Investigador/a)
Programa 'Atracción de Talento', Personal Docente Investigador (Plan Propio de la Universidad de Sevilla) (Investigador/a)
Programa Investigadora 'Miguel Servet II', Instituto de Salud Carlos III (ISCIII) (CPII16/58 - Investigador/a)
Development of a novel therapy for the treatment of genetic variants of ¿-synuclein in Parkinson¿s Disease (RTC-2015-3309-1 - Investigador Principal Consolidado)
Towards a therapeutic vaccine for Amyotrophic lateral sclerosis: ALSVac (2106/0013 - Investigador/a)
Pruebas de Concepto Preclínicas: Estudio de la Respuesta Mediada Por Células T. (EF-1030-2012 - Investigador/a)
MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF CHAPERONE/¿-SYNUCLEIN COMPLEXES LINKED TO THE IMMUNE IMBALANCE IN PARKINSON¿S DISEASE. (SAF2012-39720 - Responsable)

Libros publicados

Roodveldt-, Cintia;Outeiro, Tiago F;Braun, Janice E:
Molecular chaperones and Neurodegeneration. Frontiers in Neurology. 2017.

Capítulos en Libros

Labrador-Garrido, Adahir;Bertoncini, Carlos W.;Roodveldt-, Cintia:
THE HSP70 CHAPERONE SYSTEM IN PARKINSON'S DISEASE. Pág. 221-246. INTECH - OPEN ACCESS PUBLISHER. INTECH - OPEN ACCESS PUBLISHER. 2011.
Roodveldt-, Cintia;Labrador-Garrido, Adahir;Izquierdo-, Guillermo;Fernández-Montesinos, Rafael;Pozo-Pérez, David:
ALPHA-SYNUCLEIN AND THE IMMUNE SYSTEM IN PARKINSON'S DISEASE.. Pág. 57-76. INTECH - OPEN ACCESS PUBLISHER. INTECH - OPEN ACCESS PUBLISHER. 2011.
Aharoni-,A;Roodveldt-, Cintia;GRIFFITHS-,AD;Tawfik-, Ds:
HIGH-THROUGHPUT SCREENS AND SELECTIONS OF ENZYME ENCODING GENES. Pág. 163-179. Wiley. Wiley. 2005.

Participación en congresos

Roodveldt-, Cintia:
Chaperones in the maintenance of proteostasis. - Baeza (Jaén), España. 2016

Asistencia a congresos

Silvera , Lucía;Sola, Alejandro;Martín-Montalvo-Sánchez, Alejandro;Roodveldt-, Cintia;Pozo-Pérez, David;Garcia, Raquel;CEJUDO-GUILLÉN, MARTA;Pérez-Cabello, Jesús Á.:
Molecular and cellular insights into VIP/ADNP neuropeptide regulation of ALS progression. Poster en Congreso. Gordon Research Conference (GRC) in 'ALS and Related Motor Diseases. Les Diablerets, Suiza. 2023
Silvera , Lucía;Roodveldt-, Cintia;Pozo-Pérez, David;Garcia, Raquel;Pérez-Cabello, Jesús Á.;Sola, Alejandro;Martín-Montalvo-Sánchez, Alejandro:
Gene editing reveals ADNP protein (Activity-Dependent Neuroprotective Protein) physiological roles in microglia and its potential implications in neur. Poster en Congreso. European Network to Cure ALS ¿ ENCALS meeting. Barcelona, España. 2023
Garcia, Raquel;Silvera , Lucía;Tebaldi, Enrico;Rodríguez-martín, Araceli;Tejada-moreno, Daniel;Sola, Alejandro;Martín-Montalvo-Sánchez, Alejandro;Pozo-Pérez, David;Roodveldt-, Cintia:
Role of MOK kinase in microglial TBK1/type-1 IFN pathway and mitochondrial function. Poster en Congreso. ENCALS Annual Meeting. . BARCELONA. 2023
Pérez-Cabello, Jesús Á.;Lall, Deepti;Baloh, Robert H.;Martínez, Salvador;Miyata, Yoshihiko;Tartaglia, Gian G.;Sawarkar, Ritwick;García-Domínguez, Mario;Pozo-Pérez, David;Roodveldt-, Cintia;Silvera , Lucía;Muñoz-Franco, Jaime;CAPILLA-GONZÁLEZ, VIVIAN;Armaos, Alexandros;Gomez, Maria;Garcia, Raquel;Yap, Xin Wen;María M. Leal-Lasarte:
MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Poster en Congreso. Amyotrophic Lateral Sclerosis (ALS) & Motor Neuron Disease. LEs Diablerets (Suiza). 2023
Pérez-Cabello, Jesús Á.;Pozo-Pérez, David;Sawarkar, Ritwick;Roodveldt-, Cintia;Silvera , Lucía;Garcia, Raquel;Gomez, Maria;Armaos, Alexandros;María M. Leal-Lasarte;Blanca, Laura;Vernon, Sabine;Tartaglia, Gian G.:
Cell signaling and gene expression regulation in microglia under TDP-43 aggregation. Poster en Congreso. Protein Homeostasis in Health & Disease, Cold Spring Harbor Laboratory. Cold Spring Harbor, - NEW YORK - ESTADOS UNIDOS, EEUU. 2022
Gómez-lima, M.;María M. Leal-Lasarte;Muñoz-Franco, Jaime;González-Sánchez, Zaira Isabel;Armaos, A.;Tartaglia, Gg.;Pozo-Pérez, David;Roodveldt-, Cintia:
Implications of MOK protein kinase in neuroinflammation linked to ALS. Poster en Congreso. Gordon Research Conference (GRC) on `Amyotrophic Lateral Sclerosis (ALS) and Related Motor Neuron Diseases¿. Mt. Snow, VT, EE.UU. 2019
Pozo-Pérez, David;Roodveldt-, Cintia;María M. Leal-Lasarte;González-Sánchez, Zaira Isabel;CABALLERO-HERNÁNDEZ, DIANA ELIA;CEJUDO-GUILLÉN, MARTA;Gómez-lima, María;Muñoz-Franco, Jaime:
New insights into the role of innate immune regulation and altered metabolic homeostasis in amyotrophic lateral sclerosis (ALS): Implications for trea. Comunicación en congreso. XV Congreso Internacional De Investigacio¿n Cienti¿fica . Santo Domingo. 2019
Gómez-lima, M.;María M. Leal-Lasarte;Muñoz-Franco, Jaime;González-Sánchez, Zaira Isabel;Armaos, A.;Tartaglia, Gg.;Pozo-Pérez, David;Roodveldt-, Cintia:
A role for MOK protein kinase in neuroinflammation linked to amyotrophic lateral sclerosis. Poster en Congreso. EMBO Workshop on "ProteinQuality Control: from Mechanisms to Disease". Costa de la Calma (Mallorca). 2019
Roodveldt-, Cintia:
Protein aggregation and neuroinflammation in neurodegenerative misfolding disease. Conferencias impartidas en Congreso. EMBO Conference on `Protein Quality Control: From Mechanisms to Disease¿. Tramontana, España. 2019
Roodveldt-, Cintia:
TDP-43 misfolding and neuroinflammation in ALS.. Conferencias impartidas en Congreso. V International Conference of the Centre for Misfolding Diseases.. Trasmina, - Bolonia, Italia. 2018
Labrador-Garrido, Adahir;Villadiego-Luque, Francisco Javier;De Genst, Erwin J.;Dobson, Christopher M.;Pozo-Pérez, David;Toledo-Aral, Juan José;Roodveldt-, Cintia:
Vaccination with alpha-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic model of Parkinson¿s disease.. Poster en Congreso. Alpha-synuclein and Parkinson¿s Disease Conference: Lessons from the past 20 years.. Barcelona, España. 2017
Roodveldt-, Cintia:
Chaperones and immunity in protein misfolding diseases. Conferencias impartidas en Congreso. IV International Conference of the Centre for Misfolding Diseases. Sevilla, España. 2016
Roodveldt-, Cintia:
Chaperones and immunity in protein misfolding diseases. Conferencias impartidas en Congreso. IV International Conference of the Centre for Misfolding Diseases. Sevilla. 2016
Roodveldt-, Cintia:
Molecular chaperones and immunity in neurodegenerative proteinopathies. Sesión plenaria en Congreso. Chaperones in the Maintenance of Cellular Proteostasis. - Baeza (Jaén), España. 2016
Roodveldt-, Cintia:
Molecular chaperones and immunity in neurodegenerative proteinopathies. Sesión plenaria en Congreso. Chaperones in the Maintenance of Cellular Proteostasis. - Baeza (Jaén), España. 2016
Roodveldt-, Cintia:
Molecular chaperones and immunity in neurodegenerative proteinopathies. Sesión no plenaria en Congreso. Chaperones in the Maintenance of Cellular Proteostasis. - Baeza (Jaén), España. 2016
Roodveldt-, Cintia:
Immunization with heat-shock protein-`chaperoned¿ ¿-synuclein as a novel immunotherapeutic strategy against Parkinson¿s Disease. Conferencias impartidas en Congreso. International Congress on Neuroimmunology & Therapeutics. California, California, San Francisco, USA. 2016
Leal-lasarte, M. Magdalena;Labrador-Garrido, Adahir;Pozo, David;Roodveldt-, Cintia:
Exogenous TDP-43 species are internalized by microglia and elicit different immune profiles dependent on co-stimulating molecules. Poster en Congreso. Cold Spring Harbor Laboratory Meetings on `Protein Homeostasis in Health and Disease¿. COLD SPRING HARBOR, EE.UU. 2016
Roodveldt-, Cintia:
Vaccination with a Grp94/alpha-synuclein combination as a novel approach for immunotherapy against Parkinson¿s disease. Poster en Congreso. Cold Spring Harbor Laboratory Meetings on `Protein Homeostasis in Health and Disease¿. COLD SPRING HARBOR, EE.UU. 2016
Mannini, Bendita;Labrador-Garrido, Adahir;Vecchi, Giulia;Fabre, B;Pozo-Pérez, David;Dobson, Christopher M.;Chiti, Fabrizio;Vendruscolo, Michele;Roodveldt-, Cintia:
Immune response triggered by aberrant protein oligomers in microglial cells. Poster en Congreso. Cold Spring Harbor Laboratory Meetings on `Protein Homeostasis in Health and Disease¿. COLD SPRING HARBOR, EE.UU. 2016
Mannini, Bendetta;Labrador-Garrido, Adahir;Leal, Maria M;Cejudo-guillen, Marta;Chiti, Fabrizio;Pozo, David;Roodveldt-, Cintia:
¿Immune response triggered by aberrant protein oligomers in microglial cells¿. Poster en Congreso. EMBL Conference `Microglia: guardian of the brain¿. Heidelberg, Germany.. . 2014
Roodveldt-, Cintia;Labrador-Garrido, Adahir;Gonzalez-Rey, Elena;Lachaud-, Christian;Guilliams, Tim;Fernández-Montesinos, Rafael;Delgado-Mora, Mario;Dobson, Chistopher M.;Pozo-Pérez, David:
Preconditioning of microglia with Parkinson-linked alpha-synuclein affects the response induced by Toll-like receptor (TLR) stimulation. Poster en Congreso. 11th International Congress of Neuroimmunology. Boston, MA (USA). 2012
Roodveldt-, Cintia;Labrador-Garrido, Adahir;Gonzalez-Rey, Elena;Caro-,Marta;Lachaud-, Christian;Waudby-,Christopher;Delgado-Mora, Mario;Dobson-,Christopher M.;Pozo-Pérez, David:
GLIAL INNATE IMMUNITY GENERATED BY NON-AGGREGATED ALPHA-SYNUCLEIN: DIFFERENCES BETWEEN WILD-TYPE AND PARKINSON DISEASE-LINKED MUTANTS.. Poster en Congreso. 10TH INTERNATIONAL CONGRESS OF NEUROIMMUNOLOGY (10) (10.2010.BARCELONA). . 2010
Labrador-Garrido, Adahir;Fernández-Montesinos, Rafael;Gonzalez-Rey-, Elena;Delgado-Mora, Mario;Pozo-Pérez, David;Roodveldt-, Cintia:
MODULATION OF THE INNATE RESPONSE BY ALPHA-SYNUCLEIN AND RELATED MUTANTS: CHARACTERIZATION OF CHEMOKINES, PROINFLAMMATORY AND REGULATORY CYTOKINES. Poster en Congreso. XXXII CONGRESO DE LA SOCIEDAD ESPAÑOLA DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR (32) (32.2009.OVIEDO, ESPAÑA). OVIEDO, ESPAÑA. 2009
Roodveldt-, Cintia;Bertoncini-,Cw.;Andersson-,A.;Van Der Goot-,A.T.;Nollen-,E.A.A.;Fernández-Montesinos, Rafael;Pozo-Pérez, David;Christodoulou-,J.;Dobson-,C.M:
MOLECULAR MECHANISMS IN PARKINSON'S DISEASE: THE HSP70/ALPHA-SYNUCLEIN CROSSTALK. Poster en Congreso. XXXII CONGRESO DE LA SOCIEDAD ESPAÑOLA DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR (32) (32.2009.OVIEDO, ESPAÑA). OVIEDO, ESPAÑA. 2009
Roodveldt-, Cintia:
ALPHA-SYNUCLEIN AGGREGATION AND THE MOLECULAR ORIGINS OF PARKINSON'S DISEASE. Conferencias impartidas en Congreso. ESTUDIANTES DE POSTGRADO Y PERSONAL CIENTIFICO-INVESTIGADOR. FACULTAD DE MEDICINA, UNIVERSIDAD DE CADIZ. 2009
Labrador-Garrido, Adahir;Fernández-Montesinos, Rafael;Gonzalez-Rey-, Elena;Delgado-, M;Pozo-Pérez, David;Roodveldt-, Cintia:
DIFFERENTIAL MODULATION OF THE NEUROINFLAMMATORY RESPONSE BY WILD-TYPE AND MUTANT ALPHA-SYNUCLEIN. Comunicación en congreso. FEBS YOUNG SCIENTISTS FORUM () (.2009.PRAGA, REPÙBLICA CHECA). PRAGA, REPÙBLICA CHECA. 2009
Roodveldt-, Cintia:
HSP70, ALPHA-SYNUCLEIN, AND THE MOLECULAR ORIGINS OF PARKINSON'S DISEASE. Conferencia Congreso no publicada. GUEST SEMINARS - CENTRO NACIONAL DE BIOTECNOLOGÍA (CNB), MADRID. () (.2009.CENTRO NACIONAL DE BIOTECNOLOGÍA (CNB), MADRID). CENTRO NACIONAL DE BIOTECNOLOGÍA (CNB), MADRID. 2009
Labrador-Garrido, Adahir;Roodveldt-, Cintia:
DIFFERENTIAL MODULATION OF THE NEUROINFLAMMATORY RESPONSE BY WILD-TYPE AND MUTANT ALPHA-SYNUCLEIN. Poster en Congreso. YOUNG SCIENTIST FORUM FEBS () (.2009.PRAGUE). PRAGUE. 2009
Roodveldt-, Cintia:
HSP70 AND SYNUCLEIN INTEREACTIONS: NEW INSIGHTS INTO THE MOLECULAR ORIGIN OF PARKINSON'S DISEASE. Conferencias impartidas en Congreso. ESTUDIANTES DE POSTGRADO Y PERSONAL CIENTIFICO-INVESTIGADOR. FACULTAD DE BIOQUIMICA MEDICA Y BIOLOGIA MOLECULAR, UNIVERSIDAD DE SEVILLA, ESPAÑA. 2008
Roodveldt-, Cintia:
PARKINSON'S DISEASE: MECHANISM OF HSP70 INHIBITION OF ALPHA-SYNUCLEIN AMYLOID FORMATION. Conferencias impartidas en Congreso. ESTUDIANTES DE POSTGRADO Y PERSONAL CIENTIFICO-INVESTIGADOR. INSTITUTO DE PARASITOLOGIA Y BIOMEDICINA "LOPEZ NEYRA" (IPBLN), (CSIC), GRANADA, ESPAÑA. 2008
Roodveldt-, Cintia;Andersson-,A;Bertoncini-,Cw;Christodoulou-,J;Pozo-Pérez, David;Dobson-,Cm:
MOLECULAR INSIGHTS INTO THE ANTI-AGGREGATION ACTIVITY OF HSP70 WITH ALPHA-SYNUCLEIN. Poster en Congreso. EMBO WORKSHOP ON PROTEIN FOLDING AND CHAPERONES () (.2007.TOMAR, PORTUGAL). . 2007
Roodveldt-, Cintia;Christodoulou-,J;Dobson-,Cm:
MECHANISM OF THE HSP70¿S INHIBITION OF ALPHA-SYNUCLEIN FIBRILLATION.. Poster en Congreso. FEBS ANNUAL MEETING () (.2007.VIENA, AUSTRIA). VIENA, AUSTRIA. 2007
Roodveldt-, Cintia:
HOW ENZYMES ACQUIRE NEW FUNCTIONS: LEARNING FROM DIRECTED EVOLUTION. Conferencias impartidas en Congreso. ESTUDIANTES DE POSTGRADO Y PERSONAL CIENTIFICO-INVESTIGADOR. PALACIO DE CONGRESOS Y EXPOSICIONES, GRANADA, ESPAÑA. 2006
Roodveldt-, Cintia;Tawfik-, Ds:
EVOLUTION OF THE PROMISCUOUS ACTIVITIES IN MEMBERS OF THE AMIDOHYDROLASE SUPERFAMILY OF ENZYMES. Poster en Congreso. GORDON RESEARCH CONFERENCE (GRC): ENZYMES AND METABOLIC PATHWAYS () (.2004.MERIDEN (NH), EEUU). MERIDEN (NH), EEUU. 2004
Roodveldt-, Cintia:
Docencia impartida- BIOQUIMICA Y BIOLOGIA MOLECULAR BASICA, Universidad de Sevilla. Conferencias impartidas en Congreso. ESTUDIANTES DE POSTGRADO Y PERSONAL CIENTIFICO-INVESTIGADOR. .
Roodveldt-, Cintia:
Mi experiencia como 'investigadora móvil'.. Conferencias impartidas en Congreso. . .

Artículos publicados

Pérez-Cabello, Jesús Á.;Lall, Deepti;Baloh, Robert H.;Martínez, Salvador;Miyata, Yoshihiko;Tartaglia, Gian G.;Sawarkar, Ritwick;García-Domínguez, Mario;Pozo-Pérez, David;Roodveldt-, Cintia;Silvera , Lucía;Muñoz-Franco, Jaime;CAPILLA-GONZÁLEZ, VIVIAN;Armaos, Alexandros;Gomez, Maria;Garcia, Raquel;Yap, Xin Wen;María M. Leal-Lasarte:
MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2023. Vol: 120. Núm: 28. 10.1073/pnas.2302143120.
Garcia, Raquel;Martín, Laura;Blanca, Laura;Pérez-Cabello, Jesús Á.;García-garcía, Raquel:
Immune Signaling Kinases in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). International Journal of Molecular Sciences. 2021. Vol: 22. Núm: 24. 10.3390/ijms222413280.
María M. Leal-Lasarte;Mannini, Benedetta;Chiti, Fabrizio;Vendruscolo, Michele;Dobson, Christopher;Roodveldt-, Cintia;Pozo-Pérez, David:
Distinct responses of human peripheral blood cells to different misfolded protein oligomers. Immunology: the journal of cells, molecules, system and technologies. 2021. Vol: 164. Núm: 2. Pág. 358-371. 10.1111/imm.13377.
Mannini, Benedetta;Chiti, Fabrizio;Dobson, Christopher M.;Roodveldt-, Cintia;Vecchi, Giulia;Labrador-Garrido, Adahir;Fabre, B.;Fani, Giulia;Muñoz-Franco, Jaime;Lilley, K.;Pozo-Pérez, David;Vendruscolo, Michele:
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers.. ACS Chemical Neuroscience. 2019. Vol: 10. Núm: 8. Pág. 3464-3478.
Villadiego-Luque, Francisco Javier;Labrador-Garrido, Adahir;Leal-lasarte, M. Magdalena;Muñoz-Franco, Jaime;De Genst, Erwin J.;Dobson, Christopher M.;Pozo-Pérez, David;Toledo-Aral, Juan José;Roodveldt-, Cintia:
Immunization with alpha-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.. Glia. 2018. Vol: 66. Núm: 1. Pág. 191-205. 10.1002/glia.23237.
Johnson, Ian P;Roodveldt-, Cintia:
Commentary: Immunochemical Markers of the Amyloid Cascade in the Hippocampus in Motor Neuron Diseases.. Frontiers in Neurology. 2017. 10.3389/fneur.2017.00105.
Leal-lasarte, M. Magdalena;Muñoz-Franco, Jaime;Labrador-Garrido, Adahir;Pozo-Pérez, David;Roodveldt-, Cintia:
Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.. The FASEB Journal. 2017. 10.1096/fj.201601163R.
Sot, B;Rubio-muñoz, A;Leal-quintero, A;Martínez-sabaneo, J;Marcela, M;Roodveldt-, Cintia;Valpuesta, Jm:
The chaperonin CCT inhibits assembly of alpha-synuclein amyloid fibrils by a specific, conformation-dependent interaction.. Scientific Reports. 2017. 10.1038/srep40859.
Labrador-Garrido, Adahir;Jackson, Sophie E;Pozo-Pérez, David;Roodveldt-, Cintia;CEJUDO-GUILLÉN, MARTA;Daturpalli, Soumya;Leal, Maria M;Klippstein-Martín, Rebecca;De Genst, Erwin J;Villadiego-Luque, Francisco Javier;Toledo-Aral, Juan José;Dobson, Christopher M:
Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the a-synuclein¿elicited immune response. The FASEB Journal. 2016. Vol: 30. Núm: 2. Pág. 564-577. 10.1096/fj.15-275131.
Caballero-hernández, Diana;Toscano, Miguel;CEJUDO-GUILLÉN, MARTA;García-Martín, María Luisa;Lopez-Enriquez, Soledad;Muñoz-Franco, Jaime;Quintana, Francisco J.;Roodveldt-, Cintia;Pozo-Pérez, David:
The 'Omics' of Amyotrophic Lateral Sclerosis.. Trends in molecular medicine. 2016. Vol: 22. Núm: 1. Pág. 53-67. 10.1016/j.molmed.2015.11.001.
Chen, Sw;Valpuesta, Jm;Dobson, Cm;Cremades, N;Drakulic, S;Roodveldt-, Cintia:
Structural characterization of toxic oligomers that are kinetically trapped during ¿-synuclein fibril formation.. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015. 10.1073/pnas.1421204112.
Labrador-Garrido, Adahir;Pozo-Pérez, David;Roodveldt-, Cintia;CEJUDO-GUILLÉN, MARTA;Klippstein-Martín, Rebecca;De Genst, Erwin J;Tomás-Gallardo, Laura;Leal, Maria M;Villadiego-Luque, Francisco Javier;Toledo-Aral, Juan José;Dobson, Christopher M:
Chaperoned amyloid proteins for immune manipulation: a-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype. Immunity, Inflammation & Disease. 2014. Vol: 2. Núm: 4. Pág. 226-238. 10.1002/iid3.39.
Tomás-Gallardo, Laura;Labrador-Garrido, Adahir;David, Pozo;Roodveldt-, Cintia;Cejudo-guillen, Marta;Klippstein, Rebecca;De Genst, Erwin J;Tomas-gallardo, Laura;Leal, Maria M;Villadiego, Javier;Toledo-aral, Juan J;Dobson, Christopher M:
Chaperoned amyloid proteins for immune manipulation: alpha-synuclein/Hsp70 shifts immunity towards a modulatory phenotype. Immunity, Inflammation & Disease. 2014. 10.1002/iid3.39.
Roodveldt-, Cintia;Pozo-Pérez, David;Labrador-Garrido, Adahir;Fernández-Montesinos, Rafael;Lachaud, Christian C;Guilliams, Tim;Fernandez-montesinos, Rafael;Benitez-Rondan, Alicia;Delgado, Mario;Dobson, Christopher M:
Preconditioning of microglia by alpha-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.. PLoS One. 2013. Vol: 8. Núm: 11.
Aprile, Francesco A;Cremades, Nunilo;Dhulesia, Anne;Stengel, Florian;Roodveldt-, Cintia;Benesch, Justin L;Tortora, P;Robinson, Carol P;Salvatella, Xavier;Dobson, Christopher M:
Hsp70 Oligomerization Is Mediated By An Interaction Between The Interdomain Linker And The Helical Lid Of The Substrate-Binding Domain. PLoS One. 2013. Vol: 8. Núm: 6.
Roodveldt-, Cintia;Andersson, August;De Genst, Erwin J.;Labrador-Garrido, Adahir;Buell, Alex K.;Dobson, Christopher M.;Tartaglia, Gian G.;Vendruscolo, Michele:
A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of ¿-Synuclein and ß-Synuclein.. Biochemistry-US. 2012. Vol: 51. Núm: 44. Pág. 8771-8778.
Mannini, Benedetta;Relini, A.;Kampinga, Harm H.;Dobson, Christopher M.;Wilson, Mark R.;Cecchi, C.;Chiti, Fabrizzio;Cascella, R.;Zampagni, M.;Van Waarde-verhagen, M.;Meehan, Sarah;Roodveldt-, Cintia;Campioni, Silvia;Boninsegna, M.;Penco, A.:
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2012. Vol: 109. Núm: 31. Pág. 12479-12484.
Roodveldt-, Cintia;Labrador-Garrido, Adahir;Caro-Moreno, Marta;Gonzalez-Rey, Elena;Caro, Marta;Fernández-Montesinos, Rafael;Lachaud-, Christian;Waudby A., Christopher;Delgado-Mora, Mario;Dobson, Christopher M.;Pozo-Pérez, David:
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and parkinson¿s disease-linked mutants.. PLoS One. 2010. Vol: 5. Núm: 10. Pág. E13481-E13481.
Roodveldt-, Cintia;Bertoncini-,Cw;Christodoulou-,J;Dobson-,C.M.;Andersson-,A;Van Der Goot-,At;Hsu-, S.T.;Fernández-Montesinos, Rafael;De Jong-,J;Van Ham-,Tj;Nollen-,Ea;Pozo-Pérez, David:
CHAPERONE PROTEOSTASIS IN PARKINSON'S DISEASE: STABILIZATION OF THE HSP70/ALPHA-SYNUCLEIN COMPLEX BY HIP. EMBO Journal. 2009. Vol: 28. Pág. 3758-3770.
Roodveldt-, Cintia;Christodoulou-,J;Dobson-,Cm:
IMMUNOLOGICAL FEATURES OF ALPHA-SYNUCLEIN IN PARKINSON'S DISEASE. Journal of Cellular and Molecular Medicine. 2008. Vol: 12. Núm: 5B. Pág. 1820-1829.
Afriat-,L;Roodveldt-, Cintia;Manco-,G;Tawfik-, Ds:
The latent promiscuity of newly identified microbial lactonases is linked to a recently diverged phosphotriesterase. Biochemistry (Moscow). 2006. Vol: 45. Núm: 46. Pág. 13677-13686.
Khersonsky-,O;Roodveldt-, Cintia;Tawfik-, Ds:
ENZYMe PROMISCUITY: EVOLUTIONARY AND MECHANISTIC ASPECTs. Current Opinion in Chemical Biology. 2006. Vol: 10. Pág. 498-508.
Aharoni-,A;Roodveldt-, Cintia;Tawfik-, Ds:
DIRECTED EVOLUTION FOR HIGH EXPRESSION AND STABILITY OF HETEROLOGOUS PROTEINS. Current Opinion in Structural Biology. 2005. Pág. 50-56.
Roodveldt-, Cintia;Tawfik-, Ds:
SHARED PROMISCUOUS ACTIVITIES AND EVOLUTIONARY FEATURES IN VARIOUS MEMBERS OF THE AMIDOHYDROLASE SUPERFAMILY. Biochemistry (Moscow). 2005. Pág. 12728-12736.
Roodveldt-, Cintia;Tawfik-, Ds:
DIRECTED EVOLUTION OF PHOSPHOTRIESTERASE FROM PSEUDOMONAS DIMINUTA FOR OVER-EXPRESSION IN E. COLI RESULTS IN STABILIZATION OF THE METAL-FREE STATE. Protein Engineering Design & Selection. 2005. Pág. 51-58.
Marcipar-,Is;Roodveldt-, Cintia;Corradi-,G;Cabeza-,Ml;Brito-,Me;Marcipar-,Aj;Silber-,Am:
IMPROVEMENT OF TRYPANOSOMA CRUZI DIAGNOSIS ROUTINE FOR CHAGAS' DISEASE BY USING THE FULL-LENGTH RECOMBINANT CALFLAGIN AND ITS C-FRAGMENT. Journal of Clinical Microbiology. 2005. Pág. 5498-5503.
Aharoni-,A;Gaidukov-,L;Khersonsky-,O;Mcq Gould-,S;Roodveldt-, Cintia;Tawfik-, Ds:
THE 'EVOLVABILITY' OF PROMISCUOUS PROTEIN FUNCTIONS. Nature Genetics. 2005. Pág. 73-76.
Marcipar-,Is;Welchen-,E;Roodveldt-, Cintia;Marcipar-,Aj;Silber-,Am:
PURIFICATION OF THE 67-KDA LECTIN-LIKE GLYCOPROTEIN OF TRYPANOSOMA CRUZI, LLGP-67, AND ITS EVALUATION AS A RELEVANT ANTIGEN FOR THE DIAGNOSIS OF HUMAN. Fems Microbiology Letters. 2003. Vol: 220. Pág. 149-154.
Silber-,Am;Marcipar-,Is;Roodveldt-, Cintia;Cabeza Meckert-,P;Laguens-,R;Marcipar-,Aj:
TRYPANOSOMA CRUZI: IDENTIFICATION OF A GALACTOSE-BINDING PROTEIN THAT BINDS TO CELL SURFACE OF HUMAN ERYTHROCYTES AND IS INVOLVED IN CELL INVASION BY . Experimental Parasitology. 2002. Pág. 217-225.

Patentes

Roodveldt-, Cintia;Márquez Infante, Celedonio;Pozo-Pérez, David;CEJUDO-GUILLÉN, MARTA;Lopez-Enriquez, Soledad: Biomarcadores para la Esclerosis Lateral Amiotrófica (ELA). Número de patente:
Roodveldt-, Cintia;Leal Lasarte, M. Magdalena;Muñoz-Franco, Jaime;Pozo-Pérez, David: Agentes moduladores de MOK para el tratamiento de enfermedades con componente inflamatorio, enfermedades neurodegenerativas, enfermedades inflamatoria. Número de patente:
Roodveldt-, Cintia;Labrador-Garrido, Adahir;Pozo, David: `Combinaciones de proteínas agregantes y chaperonas moleculares para el tratamiento de proteinopatías o enfermedades conformacionales¿. Número de patente: #P201331334

Tesis dirigidas o codirigidas

(Doctorando no grabado):
Novel molecular mechanisms and signaling pathways of microglial responses in amyotrophic lateral sclerosis (ALS) . Tesis Doctoral. 2018
(Doctorando no grabado):
Alpha-Synuclein and Immune System Crosstalk in Parkinson¿s Disease: Therapeutic approaches of its Modulation by Molecular Chaperones. Tesis Doctoral. 2017
(Doctorando no grabado):
Crosstalk between peripheral and central immunity in amyotrophic lateral sclerosis (ALS).. Tesis Doctoral. 2016