MANUEL PERNIA LEAL

Categoría
Profesor Titular de Universidad

Contacto

Correo electrónico
mpernia@us.es

Departamento

Área
Química Orgánica

Centro

Docencia

Investigación

Grupo de investigación

ESTEREOQUIMICA Y SINTESIS ASIMETRICA (ESTEREOQUIMICA Y SINTESIS ASIM)

Proyectos y contratos de investigación

Sistemas nanoestructurados direccionados por el péptido intesinal vasoactivo (VIP) como alternativas para la detección y tratamiento de cáncer de prós (PI14/01600 - Investigador/a)
Talentia posdoctoral (Investigador/a)
Contrato posdoctoral del V Plan Propio de la Universidad de Sevilla. (Investigador/a)
Caracterización preclínica de alternativas para la detección y tratamiento de cáncer de próstata basadas en nanopartículas superparamagnéticas de óxid (PI-0559-2013 MS-2 - Investigador Principal Joven)
NANOMATERIALES MULTIFUNCIONALES DIRIGIDOS A TUMORES GLIALES PARA IMAGEN MOLECULAR Y TRATAMIENTO COMBINADO MEDIANTE LIBERACION CONTROLADA DE FARMACOS Y (CTQ2017-86655-R - Investigador Principal Joven)
Gliconanoestructuras: Sistemas Biomiméticos Aplicados al Transporte de Substancias Bioactivas (P06-FQM-01601 - Investigador/a)
Nuevos Antagonistas de los Receptores NK-1: Diseño, Síntesis y Aplicación en el Tratamiento contra el Cáncer. (P06-FQM-01852 - Investigador/a)
Diseños de ligando basados en O-, N- y S glicósidos para la organización de la información quiral y biológica de los carbohidratos (CTQ2006-15515-CO2-01/BQU - Investigador/a)
PROSTECTION (267226 - Investigador Principal Joven)
Caracterización preclínica de alternativas para la detección y tratamiento de cáncer de próstata basados en nanopartículas superparamagnéticas de óxid (PI-0559-2013 - Investigador Principal Joven)
VI Plan Propio. Ayuda Suplementaria a Grupos de Investigación por el Cumplimiento del Contrato-Programa entre la CEICE y la U.S. (2017/96 - Investigador/a)
Desarrollo de Nuevos Sistemas Moleculares y Supramoleculares para una Catálisis Asimétrica Sostenible. Síntesis de Compuestos Antitumorales, Antivíric (CTQ2016-78580-C2-2-R - Investigador/a)
AYUDA SUPLEMENTARIA A GRUPOS DE INVESTIGACION POR EL CUMPLIMIENTO DEL CONTRATO-PROGRAMA ENTRE LA CEICE Y LA U.S. (Cod. 2014/809 - Investigador/a)
nanocatálisis y catálisis supramolecular: nuevas herramientas para una química verde (Investigador/a)

Asistencia a congresos

Estruch-Blasco, Manel;Calderón-Montaño, José Manuel;López-Lázaro, Miguel;Pernia Leal, Manuel:
NEW RUTHENIUM PRO-DRUGS CONTAINING HYBRID NANOMATERIALS. Poster en Congreso. XXXIX Reunión Bienal de la Sociedad Española de Química,. - Zaragoza, España. 2023
Caro-Salazar, Carlos;García-Martín, María Luisa;Pernia Leal, Manuel:
Metal ternary Ag-Au-Se chalcogenide nanoparticles as novel X-ray computed tomography contrast agents.. Ponencia en Congreso. Applied Nanotechnology and Nanoscience International Conference 2018. Berlin, - Berlin, alemania. 2018
Pernia Leal, Manuel;Caro-Salazar, Carlos;García-Martín, María Luisa:
Tailoring the outermost surfaces of magnetic nanoparticles for in vivo applications. Ponencia en Congreso. Applied Nanotechnology and Nanoscience International Conference 2018. Berlin, - Berlin, alemania. 2018
Pernia Leal, Manuel;Caro-Salazar, Carlos;Muñoz-Hernandez, Maria Del Carmen;García-Martín, María Luisa:
Nanopartículas Magnéticas para Imagen Molecular por MRI (MMRI). Ponencia en Congreso. ESMRMB 2017, 34th Annual Scientific Meeting. Barcelona, España. 2017
Caro-Salazar, Carlos;García-Martín, María Luisa;Pernia Leal, Manuel:
Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging. Poster en Congreso. ESMRMB 2017, 34th Annual Scientific Meeting. Barcelona, España. 2017
Pernia Leal, Manuel;García-Martín, María Luisa:
Effect of PEG molecular weight of superparamagnetic iron oxide nanoparticles (SPIONs) on the in vivo biodistribution by Magnetic Resonance Imaging.. Ponencia en Congreso. NanoPT 2016. BRAGA (PORTUGAL). 2016
García-Martín, María Luisa;Muñoz-Hernandez, Maria Del Carmen;Pernia Leal, Manuel:
Effect of PEG molecular weight of superparamagnetic iron oxide nanoparticles (SPIONs) on the in vivo biodistribution by Magnetic Resonance Imaging. Poster en Congreso. ESMRMB 2015, 32nd Annual Scientific Meeting. Edimburgo, Reino Unido. 2015
Pernia Leal, Manuel:
Long-circulating PEGylated Magnetic Nanoparticles for MRI-based molecular imaging. Ponencia en Congreso. Long-circulating PEGylated Magnetic Nanoparticles for MRI-based molecular imaging. Sitges. 2015
Pernia Leal, Manuel:
Tracking the controlled release of Doxorubicin from magnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip¿. Ponencia en Congreso. Tracking the controlled release of Doxorubicin from superparamagnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip. Thesaloniki (Grecia) 2012. 2012
Pernia Leal, Manuel:
¿Tracking the controlled release of Doxorubicin from magnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip. Ponencia en Congreso. ¿Tracking the controlled release of Doxorubicin from magnetic thermo-responsive polymer nanobeads in a microfluid channel on a chip¿. San Sebastián. 2012
Khiar-El Wahabi, Noureddine;Assali, M.;Pernia Leal, Manuel;Fernandez-Fernandez, Inmaculada;Baati, R.;Muñoz-García, M.;Wellinger, R.:
Supramolecular Self-Organization of Neoglycolipids on Carbon Nanotubes: New Bioactive Glyconanosystems. Poster en Congreso. 17th European Symposium on Organic Chemistry (ESOC 2011). CRETA (GRECIA). 2011
Fernandez-Fernandez, Inmaculada;Navas-García, Raquel;Suárez, B.;Pernia Leal, Manuel;Khiar-El Wahabi, Noureddine:
Organizing the Chiral Information encoded by Carbohydrates: Application in Asymmetric Catalysis. Poster en Congreso. : Challenges in Organic Chemistry and Chemical Biology (ISACS1). CALIFORNIA, SAN FRANCISCO; ESTADOS UNIDOS DE AMERICA. 2009

Artículos publicados

Recio-Jiménez, Rocio;Organero, Juan Ángel ;Khiar-El Wahabi, Noureddine;Fernandez-Fernandez, Inmaculada;Lerena, Patricia;Pozo, Esther;Calderón-Montaño, José Manuel;Burgos-Morón, Estefanía;López-Lázaro, Miguel;Valdivia-Giménez, Victoria Esther;Pernia Leal, Manuel;Mouillac, Bernard :
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity. Journal of Medicinal Chemistry. 2021. Vol: 64. Núm: 14. Pág. 10350-10370. 10.1021/acs.jmedchem.1c00793.
Caro-Salazar, Carlos;De La Fuente , Jesús Manuel ;Franco, Ricardo;Pereira, Eulalia;García-Martín, María Luisa;Gámez-Márquez, Francisco;Quaresma, Pedro;Páez, Jose María;Dominguez, Alejandro;Pearson, John R;Pernia Leal, Manuel;Beltrán-Custodio, Ana María;Fernandez, Yilian:
Fe3O4-Au core-shell nanoparticles as a multimodal platform for in vivo imaging and focused photothermal therapy. Pharmaceutics. 2021. Vol: 13. Pág. 416,1-416,22. doi.org/10.3390/pharmaceutics13030416.
Caro-Salazar, Carlos;Páez, Jose María;Beltrán-Custodio, Ana María;Pernia Leal, Manuel;García-Martín, María Luisa:
PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents. ACS Applied Nano Materials. 2021. Vol: 4. Núm: 4. Pág. 4199-4207. 10.1021/acsanm.1c00569.
Caro-Salazar, Carlos;Franco, Ricardo;Quaresma, Pedro;Pereira, Eulalia;Pernia Leal, Manuel;García-Martín, María Luisa;Oliva-Montero, José María ;Merkling, Patrick J.;Zaderenko-Partida, Ana Paula;Pozo-Pérez, David:
Synthesis and Characterization of Elongated-Shaped Silver Nanoparticles as a Biocompatible Anisotropic SERS Probe for Intracellular Imaging: Theoretic. Nanomaterials. 2019. Vol: 9. Núm: 2. 10.3390/nano9020256.
Caro-Salazar, Carlos;Pernia Leal, Manuel;García-Martín, María Luisa:
In Vivo Pharmacokinetics of Magnetic Nanoparticles. Methods in Molecular Biology. 2018. Vol: 1718. Pág. 409-419. 10.1007/978-1-4939-7531-0_24.
Materia, Maria Elena ;Pernia Leal, Manuel;Scotto, Marco ;Balakrishnan, Preethi Bala ;Avugadda, Sahitya Kumar ;García-Martín, María Luisa;Cohen, Bruce E. ;Chan, Emory M. ;Pellegrino, Teresa :
Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools. Bioconjugate Chemistry. 2017. Vol: 28. Núm: 11. Pág. 2707-2714. 10.1021/acs.bioconjchem.7b00432.
Pernia Leal, Manuel;Caro-Salazar, Carlos;García-Martín, María Luisa:
Shedding Light on Zwitterionic Magnetic Nanoparticles: Limitations for in vivo Applications. Nanoscale. 2017. Vol: 9. Pág. 8176-8184. 10.1039/C7NR01607G.
Caro-Salazar, Carlos;García-Martín, María Luisa;Pernia Leal, Manuel:
Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging. Biomacromolecules. 2017. Vol: 18 . Núm: 5. Pág. 1617-1623. 10.1021/acs.biomac.7b00224.
Caro-Salazar, Carlos;Dalmases, Mariona ;Figuerol, Albert ;García-Martín, María Luisa;Pernia Leal, Manuel:
Highly water-stable rare ternary Ag¿Au¿Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents. Nanoscale. 2017. Vol: 9. Núm: 21. Pág. 7242-7251. 10.1039/c7nr01110e.
Khiar-El Wahabi, Noureddine;Assali-, Mohyeddin;Pernia Leal, Manuel;Cid-Martín, Juan José;Valdivia-Giménez, Victoria Esther;Fernandez-Fernandez, Inmaculada;Wellinger-, Ralf Erik:
Carbon-based glyco-nanomaterials : a smart tool for the selective aggregation of bacteria and advanced drug delivery. Abstracts, 28th International Carbohydrate Symposium, ACS. 2016. Vol: 2016.
Pernia Leal, Manuel:
Mesoscale Assemblies of Iron Oxide Nanocubes as Heat Mediators and Image Contrast Agents. Langmuir. 2015.
Pernia Leal, Manuel:
Instructable Nanoparticles Using Dynamic Combinatorial Chemistry. Langmuir. 2015.
Pernia Leal, Manuel;Assali, M.;Cid, J.j.;Valdivia-Giménez, Victoria Esther;Franco, J.m.;Fernandez-Fernandez, Inmaculada;Pozo, D.;Khiar-El Wahabi, Noureddine:
Synthesis of 1D-Glyconanomaterials by a Hybrid Noncovalent-Covalent Functionalization of Single Wall Carbon Nanotubes: a Study of their Selective Inte. Nanoscale. 2015. Núm: 7. Pág. 19259-19272.
Pernia Leal, Manuel;Muñoz-Hernandez, Maria Del Carmen;Berry, Catherine C.;García-Martín, María Luisa:
In vivo pharmacokinetics of T2 contrast agents based on iron oxide nanoparticles: optimization of blood circulation times. RSC Advances. 2015. Vol: 5. Núm: 94. Pág. 76883-76891. 10.1039/C5RA15680G.
Fernandez, TD;Pernia Leal, Manuel;Torres-Jaen, Maria Jose;Mayorga-Mayorga, Cristobalina:
Intracellular accumulation and immunological properties of fluorescent gold nanoclusters in human dendritic cells. Biomaterials. 2015.
Pernia Leal, Manuel:
Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)Responsive Coating and Their Application in Hyperthermia and Heat-Triggered . ACS Applied Materials and Interfaces. 2015.
Pernia Leal, Manuel;Rivera-fernandez, Sara;Muñoz-Franco, Jaime;Pozo-Pérez, David;De La Fuente, Jesús;García-Martín, María Luisa:
Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging. Nanoscale. 2015. Vol: 7. Núm: 5. Pág. 2050-2059. 10.1039/c4nr05781c.
Pernia Leal, Manuel:
Ligand effect on the size, valence state and red/ near infrared photoluminescence of bidentate thiol gold nanoclusters. Nanoscale. 2014.
Pernia Leal, Manuel:
Synthesis and non-covalent functionalization of carbon nanotubes rings: new nanomaterials with lectin affinity. Nanotechnology. 2013.
Pernia Leal, Manuel:
Atomic Ligand Passivation of Colloidal Nanocrystal Films via their Reaction with Propyltrichlorosilane. Chemistry of Materials. 2013.
Pernia Leal, Manuel:
Glyconanosomes: Disk-Shaped Nanomaterials for the Water Solubilization and Delivery of Hydrophobic Molecules. ACS Nano. 2013.
Pernia Leal, Manuel:
Controlled Release of Doxorubicin Loaded within Magnetic Thermoresponsive Nanocarriers under Magnetic and Thermal Actuation in a Microfluidic Channel. ACS Nano. 2012.
Khiar-El Wahabi, Noureddine;Pernia Leal, Manuel;Navas-García, Raquel;Moya-López, Juan Francisco;García-Pérez, Maria Victoria:
P/S ligands derived from carbohydrates in Rh-catalyzed hydrosilylation of ketones . Organic and Biomolecular Chemistry. 2012. Vol: 10. Núm: 2. Pág. 355-360.
Pernia Leal, Manuel:
Copper-Catalyzed Azide¿Alkyne Cycloaddition in the Synthesis of Polydiacetylene: ¿Click Glycoliposome¿ as Biosensors for the Specific Detection of Lec. Chemistry: A European Journal. 2011.
Pernia Leal, Manuel:
¿Nanohybrids¿ Based on pH-Responsive Hydrogels and Inorganic Nanoparticles for Drug Delivery and Sensor Applications. Nano Letters. 2011.
Pernia Leal, Manuel:
Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads. Advanced Materials. 2011.
Pernia Leal, Manuel:
Improved Non-Covalent Biofunctionalization of Multi-Walled Carbon Nanotubes Using Carbohydrate Amphiphiles with a Butterfly-Like Polyaromatic Tail. Nano Research. 2010.
Khiar-El Wahabi, Noureddine;Pernia Leal, Manuel;Baati-,Rachid;Mioskowsky-,Charles;Fernandez-Fernandez, Inmaculada:
TAILORING CARBON NANOTUBES SURFACES WITH GLYCONANORINGS: NEW BIONANOMATERIALS WITH SPECIFIC LECTIN AFFINITY. Chemical Communications. 2009. Pág. 4121-4123.
Pernia Leal, Manuel:
C2-Symmetric Bissulfoxides as Organocatalysts in the Allylation of Benzoyl Hydrazones: Spacer and Concentration Effects. Organic Letters. 2007.

Patentes

Khiar-El Wahabi, Noureddine;Pernia Leal, Manuel;Fernandez-Fernandez, Inmaculada: Neoglycolipids, used to prepare supramolecular aggregates with carbon nanotubes for medical or diagnostic applications. Número de patente: ES2329218-A1